Multicenter Automatic Defibrillator Implantation Cardiac Resynchronization Therapy Trial (MADIT-CRT)

Sponsor: Guidant Corporation

Investigators:
Ishu Rao, MD*
Brad Leonard, MD


Designated Site: Baylor Regional Medical Center Plano

This study is designed to decide if Cardiac Resynchronization Therapy (CRT) along with an Implantable Cardiac Defibrillator (ICD) will slow or stop progression of heart failure. The two of these combined is called Cardiac Resynchronization Therapy and Defibrillation (CRT-D). We know that patients with advanced heart failure have a decrease in hospitalizations and symptoms with CRT-D. The purpose of this study is to decide if people who have impaired heart function will have improved survival and less heart failure with implantation of an automatic defibrillator device that can also pace the heart more efficiently using resynchronization (CRT-D) when compared to people treated with only an implanted defibrillator (ICD-only).

* denotes Principal Investigator