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CRSTI Research News - August 2001
Emerging Techniques for Venous Disease
by Jon Senkowsky, M.D.
Venous disease is a long recognized problem that affects almost everyone. Problems with veins often lead to swelling, heaviness in the legs, varicose veins, spider veins, and even ulcerations and blood clots, which are potentially life threatening. Despite the fact venous disease has been acknowledged since the time of Hippocrates hundreds of years B.C., innovative technology and significant diagnostic advances in treating venous disease are finally emerging in the field of vascular surgery.
Complications with veins occur for the simple reason they are always working against gravity. Veins in the legs carry blood from the leg to the heart. In order to cover this long distance efficiently, veins contain valves that allow blood to move up the leg, and not down. If these valves become destroyed, blood pools in the lower portion of the leg causing leg swelling, varicose veins and other venous problems. Typical symptoms include heaviness in the legs, swelling, development of varicose veins, and even skin damage, dry skin, and brownish pigmentation at the ankle level leading to ulcers. Another more serious symptom includes blood clots in the legs. Indeed, recent reports indicate people who frequently fly in airplanes are at risk of developing blood clots, which can break free and cause pulmonary emboli. However, the majority of people present with chronic problems in the legs. The most effective treatment can be found by making an accurate diagnosis; determining if blood clotting is present; and identifying whether any venous valve disorders are present. Valve disorders often indicate venous reflux, or pooling of the blood located in the deep veins of the muscle or on the surface veins underneath the skin. (The surface veins, when enlarged, are actually varicose veins.) By utilizing a machine called a Duplex Scan, a noninvasive and painless diagnostic test, all these questions can be answered. Once an accurate and thorough diagnosis is made, there are numerous techniques that can be used to treat venous disease. Perhaps the simplest and most well known treatment for venous disease is the compression garment. These are essentially tight hose or wraps that control the swelling in the leg by forcing the blood into the deeper veins. The compression garments force the same amount of blood into a smaller volume of veins, resulting in more efficient removal of the blood from the lower extremities. A variety of different hose products, both knee high, thigh high, and waist high, and a variety of different strengths and colors, are now available. Other techniques, such as lymphedema wraps and massaging can be administered in order to decrease the swelling associated with venous disease. Finally, an extremity pump, a device that resembles a pant leg is connected to an air pump. The pump blows up the pant legs like a balloon, in order to decrease edema, or swelling, at the lower extremities.
In cases where these noninvasive techniques do not work, or alternatively in patients who desire a better cosmetic result from their venous disease, there are a multitude of techniques to decrease the size of the surface veins. These include ligation, or tying off of the appropriate veins, which can be performed through small incisions under local anesthesia in an outpatient setting. Another technique for surface varicose veins includes a micro-stab avulsion, a treatment in which surgeons use a small needle to surgically remove the vein, again under local anesthesia. This minimally invasive approach replaces the traditional procedure of vein stripping, a technique that formerly left patients with large incisions and scars. Other techniques include sclerotherapy. These are injections of a solution primarily into spider veins and smaller veins that irritate the vein causing them to clot off. This approach, when utilized with compression, can result in essentially the disappearance of the veins and is most effective for spider veins. Perhaps, the most effective techniques to treat painful varicose veins involve vein stripping without removing the vein. These include the VNUS Closure Device and the Laser. In these techniques, a needle is inserted into the saphenous vein, which is the main surface vein in the leg. A catheter is then inserted into the saphenous vein and either ultrasound (utilizing the VNUS device) or laser light, (utilizing the laser device), is applied to the vein causing it to clot off. This decreases the backpressure on the lower leg, reducing the size of the varicose veins. Again, these techniques, which are performed under local anesthesia, can achieve tremendous results in the lower extremity varicose veins.
New techniques in the treatment of varicose veins are emerging. However, the techniques must be applied in the appropriate setting for them to be effective. Therefore, an accurate diagnosis with ultrasound and physical examination are essential to the quality of care for the treatment of varicose veins. Applied correctly, current and future technology offer great promise in the improvement, symptomatology and appearance of varicose veins and its associated complications.
Dr. Jon Senkowsky is a practicing vascular surgeon with COR Specialty Associates of North Texas, PA (CSANT) and The Varicose Vein Clinic of Texas in Fort Worth.
Research Staff Profile
Tina Worley, RN, BSN, CCRC
Clinical Regulatory Manager
Tina Worley is the Clinical Regulatory Manager for CRSTI. Tina has 11 years of cardiac nursing experience, five of which have been in cardiac clinical research.
Tina joined CRSTI in October 2000. As Clinical Regulatory Manager of Research, she is involved in the coordination of the beginning phases of clinical trials. Some of her responsibilities include Institutional Review Board submissions, budgets, site agreements, correspondence with sponsors, management and maintenance of study data. As a Research Coordinator, she is involved in working with physicians and patients, completing study visits, collecting data, organizing spreadsheets and communicating with sponsors.
Tina graduated from the University of Texas, San Antonio with a Bachelor of Science in Nursing in 1990. After graduation, she moved to Corpus Christi where she worked at Sophn Hospital as a RN on the cardiac unit. In 1996, she went to work for Heart Associates of South Texas as an office nurse and research coordinator. From there, she transferred to Cardiology Associates of Corpus Christi where she continued in research. Since joining CRSTI, Tina has obtained her certification as a clinical research coordinator through ACRP in March of 2001.
Calendar
SEPTEMBER
September 3 - Labor Day
September 5 - Abstract Submission Deadline-ACC
September 18 - CRSTI Education Committee Mtg.
September 19 - IRB Meeting at MCD Hospital
September 20 - IRB Meeting at PHD
September 28 - Advances in Cardiac Surgery -Off-Pump Coronary Artery Bypass Course
September 29 - American Heart Walk
OCTOBER
October 12 - Echocardiography Review Course
October 16 - CRSTI Education Committee Mtg.
October 17 - IRB Meeting at MCD Hospital
October 19 - Abstract Submission Deadline-AATS
October 25 - IRB Meeting at PHD
NOVEMBER
November 12 - Abstract Submission Deadline-Aortic Surgery Symposium VIII
November 21 - IRB Meeting at MCD Hospital
November 22 - Thanksgiving Day
November 29 - IRB Meeting at PHD
CRSTI Investigator Meetings are held every Thursday morning at 7:00 a.m. at Medical City Dallas Hospital. For more information regarding any of the meetings, please call 214-750-7005.
Teaching OPCAB to Surgeons From Around the Nation
Four CRSTI researchers were selected to teach a new heart bypass operation without using the heart-lung machine, to a select group of their peers from around the country on June 11 and 12. The unique continuing medical education program, sponsored by the Society of Thoracic Surgeons (STS) and co-produced by the Cardiopulmonary Research Science and Technology Institute (CRSTI) and the Cleveland Clinic.
Twenty-four of the nation's selected cardiovascular and thoracic surgeons received highly-skilled training in Beating Heart, or OPCAB (off-pump coronary artery bypass) surgery, from some of the country's pioneers in cardiac surgery. Twelve surgeons at each of the two training sites - the Cleveland Clinic and the Presbyterian Institute for Minimally Invasive Technology (or PIMIT) at Presbyterian Hospital of Dallas - interacted through telesurgery capabilities while experts performed different techniques of Beating Heart bypass surgery. The training setup allowed the classroom surgeons to receive broadcast-quality images from the operating room, hear a physician moderator lecture them through the procedure, and pose questions from the classroom to the OR at both sites.
"The caliber of the physicians who served as faculty for this training program are among the best in the country at performing this cutting edge bypass technique," said Donald Turney, Society of Thoracic Surgeons. "Their level of expertise, coupled with modern technology, allows established physicians to participate with their peers, as they potentially alter the future of bypass surgery as we know it."
The Beating Heart bypass operation is done without the need to stop the heart and circulate the blood artificially, thus avoiding the associated risks and complications of the heart-lung machine, including stroke and other neurological disorders. Only fifteen percent of the bypass operations in the U.S. last year were performed through beating heart techniques, although experts predict the number of these procedures will escalate as more surgeons are trained in the techniques. Some of the reported benefits from OPCAB include decreased mortality, reduced length of stay, fewer complications and quicker recovery time. The two-day, hands-on training course was designed to demonstrate the use of three different technologies in performing this revolutionary approach to bypass surgery.
"We applaud STS for their initiative in developing this innovative approach to continuing medical education," said Mitch Magee, MD, CRSTI Medical Director and faculty for the Off-Pump Surgery Training Program. "An added benefit to this course is the proctorship that follows."
For the first time in its history, STS is arranging for faculty of the Off-Pump Program to proctor the attendees after they completed the two-day training. The trainees will visit an assigned preceptor's institution and observe multiple off-pump cases in the operating room, while also engaging in extensive discussions with the preceptor about the technical aspects of the surgery. The clinical preceptor will then visit the trainee's institution to observe his performance of off-pump bypass surgery. The trainees will be expected to submit the outcomes of their cases during the first year. Outcomes will be evaluated by an STS committee to assess the impact of this multi-faceted training on their performance and on patient quality of care.
Bachand to Address Graduating Nurses in Bangalore
Donna Bachand, RN, PhD, Associate Director of Clinical Research for CRSTI, has been invited to give the graduation address to twenty nurses at the Rebekah A. Naylor School of Nursing in Bangalore, India on August 25, 2001. Dr. Bachand was selected for her volunteer efforts with the school and her leadership as President of Sigma Theta Tau International, Beta Beta Chapter, at Texas Women's University.
In addition to the commencement address, entitled "Why the World Needs Nurses - Making a Difference in the Community in Which You Live," Dr. Bachand has been granted a two-week visiting scholarship at the Bangalore Baptist Hospital. During her stay, she plans to present daily seminars on new research methodologies to the nursing faculty; teach post-graduate courses to the hospital staff; share evidenced-based research findings with physicians; and participate in palliative care with doctors and patients within the community. The latter of which she noted being of particular interest.
"The most exciting thing about this visit to me is the opportunity to provide palliative care," says Bachand. "I am excited to go out into the community and work directly with the doctors and their patients in this community-based patient care program." Many of these patients are diagnosed with terminal cancer, heart disease and lung disease according to Bachand. She says she is ready to put her extensive training to work and make a difference in the quality of life for these people suffering from these deadly diseases.
The Naylor nursing program was developed just three years ago and depends on the voluntary efforts of individuals such as Dr. Bachand to provide advanced education to the students. Says Bachand, "I expect to learn as much as I teach."
Students Intern with National Pioneers in Cardiac Research
Laura Ley and Shannon Horswell of The Greenhill School, Aron Rosenstock of Washington University and Sabrina Chen of Plano Senior High successfully completed their six-week internship at the Cardiopulmonary Research Science and Technology Institute (CRSTI). The four were recognized at a special reception on Tuesday, July 31 at the Cooper Clinic Guest Lodge in Dallas, Texas.
These students were selected from a number of Dallas-Fort Worth applicants, both high school and college-level, to participate in the organization's Summer Internship Program. Each year, CRSTI selects four students from the community to participate in the paid, six-week program, encouraging their pursuit of a medical career.
The interns spent the last several weeks learning about the concepts of clinical and pre-clinical research, basic scientific principles of research, clinical outcomes, and data collection and management. Each was assigned his/her own specific research project, and paired with a physician mentor to assist them in completing their assignment. Mentoring clinicians included Dr. Jorge Cheirif, Dr. Todd Dewey, Mike Fuller, PA-C, Dr. Morley Herbert, PhD, Dr. Jeffrey Horswell, Lisa Johnson, ACNP, Dr. Michael Mack, Dr. Mitchell Magee, Angela Riley, RT, Dr. Will Ryan, Dr. Mitchel Sklar, Dr. John Tan, and Dr. Christopher Wyndham.
All students were held accountable for their assigned tasks, providing progress reports to their designated mentor. Each student had the opportunity to take ownership in one project of interest and take it from infancy to completion. For many, this opportunity allows them to co-author a study for national and/or international publication, an accomplishment that is normally not achieved until one is well into medical school.
CRSTI Summer Intern Program sponsors included: AlphaGraphics, Dr. and Mrs. James Edgerton, Mr. and Mrs. Tom Hurtekant, Dr. and Mrs. Will Ryan, Dr. and Mrs. Phillip Scruggs, and an Anonymous Donor.
Echocardiography Review Course
Physicians and sonographers from across the United States will be convening for the fourth annual, CRSTI sponsored, Echocardiography Review Course on October 12 in Dallas. This one-day comprehensive forum focuses on the issues pertinent to today's physicians and sonographers including technological advancements in echocardiography. The faculty represents experts in echocardiography from across the nation. For more information or to register for this course visit http://www.crsti.org/education.html or call the CRSTI Education Department at 214-750-7005 x106.
CRSTI Research Protocols
CRSTI currently maintains several protocols with active enrollment. CLICK
HERE for a description of current protocols, including sponsors, investigators
and designated sites.
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